Pan Melanoma + S100

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Pan Melanoma Antibody +S100 (Tyrosinase) is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB45.
MART-1 (M2-7C10 + M2-9E3) recognizes a protein of 18kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1). MART-1 is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. This MART-1 does not stain steroid tumors unlike Melan A [103].
S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal, Rabbit Polyclonal

Clone

T311 + M2-7C10 + M2-9E3+N/A

Isotype

IgG2a+ IgG2b/kappa + IgG2b /kappa + N/A

Antigen

Tyrosinase, MART-1, S100 protein

Localization

Tyrosinase: (cytoplasmic); brown, MART-1: (cytoplasmic); brown S100: (nuclear/cytoplasmic); red

Positive Control

Melanoma

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Shidham VB et al., Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with ‘MCW melanoma cocktail’–a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase. BMC Clin Pathol. 2007 Mar 7;7:2.
2. Orchard G. Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody. Br J Biomed Sci. 2002;59(4):196-202
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. National Committee for Clinical Laboratory Standards(NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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