Pan Cytokeratin [Lu-5]

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Pan Cytokeratin [Lu-5] antibody is has been demonstrated as a useful marker for the differentiation of epithelial and mesothelial cells from mesenchymal cells in normal and tumor tissues. It has been shown to serve as a first-order pan cytokeratin antibody for both acidic (type I) and basic (type II) cytokeratin subfamilies of all vertebrates tested so far. In immunohistochemical studies, [Lu-5] stains an intracytoplasmic, formaldehyde-resistant epitope on the surface of cytokeratin filaments. [Lu-5] has been shown to be superior to [AE1/AE3].

Intended Use

IVD

Species Reactivity

Human, Mouse, Rat

Source

Mouse Monoclonal

Clone

Lu-5

Isotype

IgG1

Antigen

Pan Cytokeratin

Localization

Cytoplasmic

Positive Control

Skin or adenocarcinoma

1. Schroder S, Wodzynski A, Padberg B. Cytokeratin expression of benign and malignant epithelial thyroid gland tumors. An immunohistologic study of 154 neoplasms using 8 different monoclonal cytokeratin antibodies. Pathologe 1996 Nov;17(6):425-432.
2. Mullhaupt B, Gudat F, Epper R, Bianchi L. The common pattern of cytokeratin alteration in alcoholic and cholestatic liver disease is different from that of hepatic liver damage. A study with the panepithelial monoclonal antibody lu-5. J Hepatol 1993 Aug;19(1):23-35.
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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