p63 (PulmoPanel™)

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Tumor protein p63 antibody, also known as transformation-related protein 63 is a protein that in humans is encoded by the TP63 gene. Many studies have shown that p63 is a sensitive (90%) and fairly specific marker for squamous cell carcinoma and may be used in distinguishing poorly differentiated lung squamous cell carcinomas (SqCC) from adenocarcinomas. p63 has been shown to mark approximately 5 to 10% of lung adenocarcinomas.
p63 is a nuclear stain and has been specially titered for lung SqCC. This optimized p63 antibody is part of the PulmoPanel™ set used for discriminating between lung adenocarcinoma vs. lung SqCC.
A combination of p63 and TRIM29 can also be utilized for lung SqCC and studies have shown that when p63 and/or TRIM29 is expressed in lung SqCC, a 95.4% sensitivity and 100% specificity was achieved, if Napsin A and TTF-1 were both negative in the same case.
*Part of the PulmoPanel™ Kit for diagnosing lung cancer, to order use Cat. No. PPM 435 AAK.
The PulmoPanel™ Kit includes: CK5, Desmoglein 3, Napsin A, p63, TRIM29 and TTF-1.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

BC4A4

Isotype

IgG2/kappa

Antigen

p63

Localization

Nuclear

Positive Control

Lung squamous cell carcinoma

1. Iacono ML, et al. p63 and p73 Isoform Expression in Non-small Cell Lung Cancer and Corresponding Morphological Normal Lung Tissue. J Thorac Oncol. 2011 Mar; 6 (3):473-81.
2. Tacha D, Yu C, Haas T. TTF-1, Napsin A, p63, TRIM29, Desmoglein-3 and CK5: An Evaluation of Sensitivity and Specificity and Correlation of Tumor Grade for Lung Squamous Cell Carcinoma vs. Lung Adenocarcinoma. Modern Pathology; USCAP, 2011 (Abstract Accepted)
3. Mukhopadhyay S, Katzenstein AL. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011 Jan; 35(1):15-25.
4. Tacha D, Zhou D, Henshall-Powell RL. Distinguishing Adenocarcinoma from Squamous Cell Carcinoma in Lung Using Double Stains p63+ CK5 and TTF-1 + Napsin A. Modern Pathology; Pathology Volume 23, Supplement 1, Feb 2010; Abstract 1852, page 222A.
5. Conde E, et al. The use of P63 immunohistochemistry for the identification of squamous cell carcinoma of the lung. PLoS One. 2010 Aug 17; 5(8):e12209.
6. Uke M, et al. The use of p63 as an effective immunomarker in the diagnosis of pulmonary squamous cell carcinomas on de-stained bronchial lavage cytological smears. Cytopathology. 2010 Feb; 21(1):56-63. Epub 2009 Sep 9.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
8. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991; 7(9). Order code M29-P.

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