p53 Tumor Suppressor Protein

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p53 has been observed to act as both as a tumor-suppressor and transcription factor. p53 activation by DNA damage or other stress signals is reported to trigger DNA repair, cell-cycle arrest, or apoptosis. The nuclear p53 gene is located on chromosome 17p, a frequent site of allele loss in many tumors (60%) including breast, colon and lung. p53 Tumor Suppressor Protein antibody mouse monoclonal has also been shown to have prognostic utility for distal colorectal cancer and nasopharyngeal carcinoma by the assessment of mutation and overexpression status.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

DO-7

Isotype

IgG2b/kappa

Antigen

p53

Localization

Nuclear

Positive Control

Breast and colon carcinomas

1. Suthipintawong C, Leong AS, Chan KW, Vinyuvat S. Immunostaining of estrogen receptor, progesterone receptor, MIB1 antigen, and c-erbB-2 oncoprotein in cytologic specimens: a simplified method with formalin fixation. Diagn Cytopathol. Aug; 17 (2):127-133, 1997.
2. Alexiev BA, Bassarova AV, Popovska SL, Popov AA, Christov CZ. Expression of c-erbB-2 oncogene and p53 tumor suppressor gene in benign and malignant breast tissue: correlation with proliferative activity and prognostic index. Gen Diagn Pathol. Jun; 142(5-6):271-279, 1997.
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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