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p120 Catenin, 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer p120 Catenin, catalog numbers ACI3008, API3008 as a substitute.
p120 catenin plays a role in cytoskeletal anchoring in the adherens junctions between epithelial cells (1-2). In normal tissues, immunostaining of p120 is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex.
In breast ductal neoplasia, p120 staining is usually observed in cellular membranes. However, in lobular neoplasia, a marked redistribution of p120 throughout the cytoplasm typically results in a diffuse cytoplasmic staining pattern for p120. (1,3-4).
Staining of p120 and E-cadherin has been shown to be complementary and aid in the accurate categorization of ductal and lobular neoplasms, including the distinction between low-grade ductal carcinoma in situ and lobular neoplasia (2).
Additionally, in a survey of various neoplastic tissues, some rectal and gastric adenocarcinomas demonstrated diffuse cytoplasmic p120 staining and a lack of membranous p120 staining, mimicking the staining pattern observed with lobular breast neoplasms (2).
Cytoplasm (lobular carcinoma) or membrane (ductal cell carcinoma)
Normal breast or breast lobular carcinomas
1. de Deus Moura R, et al. Immunohistochemistry Applied to the Differential Diagnosis Between Ductal and Lobular Carcinoma of the Breast. Appl Immuohistochem Mol Morphol. 2012 May 16 Epub ahead of print.
2. Dabbs DJ, Bhargava R, Chivukula M. Lobular Versus Ductal Breast Neoplasms: The Diagnostic Utility of P120 Catenin. Am J Surg Path. 2007;31:427-437.
3. Sarrio D, et al. Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. Oncogene. 2004;23:3272-3283.
4. Mastracci TL, et al. E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breast. Mod Path. 2005;18:741-751.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.