Neurofilament

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Neurofilaments antibody are the intermediate filaments of neurons. Studies have shown this antibody stains the 70 kDa and 200 kDa polypeptides of neurofilaments. It stains neurons in tissue sections of brain and other tissues. It does not cross-react with other intermediate filaments such as GFAP, keratin, vimentin and desmin and does not react with small cell lung carcinoma. Neurofilament [2F11] has been shown to react with neuroblastomas, gangliomas, pheochromocytomas, Merkel cell tumors and carcinoid tumors.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

2F11

Isotype

IgG1 /kappa

Antigen

Neurofilament

Localization

Cytoplasmic

Positive Control

Normal Brain

1. Diepholder HM, Schwechheimer K, Mohadjer M, Knoth R, Volk B. A clinicopathologic and immunomorphologic study of 13 cases of ganglioglioma. Cancer 1991 Nov 15;68(10):2192-201.
2. Franquemont DW, Mills SE, Lack EE. Immunohistochemical detection of neuroblastomatous foci in composite adrenal pheochromocytoma-neuroblastoma. Am J Clin Pathol 1994 Aug;102(2):163-70
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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