Myogenin

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Myogenin is a member of a family of myogenic genes that also includes MyoD. These genes encode a set of transcription factors that are essential for muscle development. Expression of myogenin is restricted to cells of skeletal muscle origin. Myogenin antibody has been shown to label human myogenin and label neonatal mouse, rat and cat tissues. Staining has also been found in myoblasts from human fetal limbs. No reactivity was found in adult skeletal muscle. Myogenin has been observed to stain the vast majority of rhabdomyosarcomas and Wilm’s tumors. No activity was observed in Ewing’s sarcoma/peripheral primitive neuroectodermal tumor, or in neuroblastomas.

Intended Use

IVD

Species Reactivity

Cat, Human, Mouse, Rat

Source

Mouse Monoclonal

Clone

MyG007 (also known as F5D)

Isotype

IgG1 /kappa

Antigen

Myogenin

Localization

Nuclear

Positive Control

Rhabdomyosarcoma

1. Zhu BL, et al. Changes of myocardial myoglobin, myosin and creatine kinase in cases of sudden nocturnal death syndrome. Chin Med J (Engl) 1994 Jan;107(1):36-40.
2. Kock KF, Simonsen KW. Renal myoglobin in drug addicts: occurrence and significance in a postmortem study. Forensic Sci Int 1994 Mar 25;65(2):113-9.
3. Horike K, et al. Relation between myoglobin and cardiac dysfunction in myocarditis–immunohistochemical study endomyocardial biopsy specimens. Jpn Circ J 1991 Jan;55(1):24-32.
4. Leader M, et al. Myoglobin: an evaluation of its role as a marker of rhabdomyosarcomas. Br J Cancer 1989 Jan;59(1):106-9.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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