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Deletions of chromosome 6q are found in many types of cancer, including melanoma, prostate cancer, fibroadenomas, and carcinoma of breast and other sites1. Chromosome 6q deletions are also commonly found in lymphoid malignancies such as acute lymphocytic leukemia (ALL), approx 30% of cases2; chronic lymphocytic leukemia (CLL), non-Hodgkins lymphoma (NHL), approx 7%, multiple myeloma (MM), mantle zone lymphoma (MZL), and Waldenström’s macroglobulinemia (WM)3.
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1. Brigaudeau C and Bilhou-Nabera C. Del(6q) abnormalities in lymphoid malignancies. Atlas Genet Cytogenet Oncol Haematol. December 1998.
2. 6q Deletions in Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphomas Mats Merup, Teresa Calero Moreno, Mats Heyman, Kristina Rönnberg, et al. Blood, Vol 91, No 9 (May 1), 1998: pp 3397-3400
3. Sinclair PB, Sorour A, Martineau M, Harrison CJ, Mitchell WA, O’Neill E, Foroni L. A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene. Cancer Res. 2004;64:4089-4098.
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.