MUC-4

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MUC-4 (also called sialomucin complex) is a membrane-bound mucin that has been suggested to be implicated in malignant progression in humans and rats. The MUC-4 antibody gene is expressed in various normal epithelial tissues of endodermic origin and carcinomas. In the respiratory tract, over-expression of the membrane mucin has been observed during malignant progression of mammary tumors in both humans and rats, suggesting that deregulation of MUC-4 might facilitate development of these malignancies. Studies have indicated that over-expression of MUC-4 results in suppression of both cell adhesion and immune killing of tumor cells. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. Other studies have shown that MUC-4 is a very specific (100%) and sensitive (91.4%) marker of lung adenocarcinomas and is negative for mesotheliomas. MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis and predicts outcome in the patient.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

9G-7

Isotype

IgG1/kappa

Antigen

MUC-4

Localization

Cell membrane/cytoplasm

Positive Control

Lung cancer

1. Zhang S, Zhang HS, Cordon-Cardo C, Ragupathi G, Livingston PO. Selection of tumor antigens as targets for immune attack using immunohistochemistry: protein antigens. Clin Cancer Res. 1998 Nov;4(11):2669-76.
2. Llinares K, Escnade F et al. Diagnostic value of MUC4 immunostaining in distinguishin epithelial mesothelioma and lung adenocarcinoma. Mod Pathol. 2004 Feb;17(2):150-7.
3. Saitou M, Goto M et al. MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. bJ Clin Pathol. 2005 Aug;58(8):845-52.
4. Price-Schiavi SA et al. Rat Muc4 (sialomucin complex) reduces binding of antiErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance. Int J Cancer. 2002 Jun 20;99(6):783-91.
5. Komatsu M, Jepson S et al. Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransfplanted tumor. Oncogene. 2001 Jan 25;20(4):461-70.
6. Idris N, Carraway KL. Sialomucin complex (Muc-4) expression in the rat female reproductive tract. Biol Reprod. 1999 Dec;61(6):1431-8.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
8. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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