MAF (16q23) Orange FISH Probe

SKU: HFI7284A Categories: ,

The MAF gene encodes for a protein that is a DNA-binding, leucine zipper-containing transcription factor which, depending on binding site and partner, can act as a transcriptional activator or repressor. The protein plays a part in many cellular process associated with development and differentiation1. In combination with IGH probes reserach has shown that this probe can be used to detect the fusion event of IGH and MAF which is a common genomic alteration in multiple myeloma2.

FOR DISTRIBUTION OUTSIDE THE UNITED STATES ONLY

Intended Use

IVD

Volume

100 µl

Species Reactivity

Human

Color

Orange

Download OUS Datasheet

Legal Notice

IVD is NOT for Sale in the United States but may be available in certain countries outside of the United States, please contact your local distributor for more information.

1. Overexpression of c-Maf Contributes to T-Cell Lymphoma in Both Mice and Human. Naoki Morito, Keigyou Yoh, Yuki Fujioka, Takako Nakano, Homare Shimohata, Yuko Hashimoto, et al. Cancer Res 2006; 66: (2). Jan 15.
2. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL,Kuehl WM, Staudt LM. Cancer Cell. 2004 Feb; 5(2):191-9.

3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.