Leukocyte Common Antigen (CD45RB)

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Leukocyte Common Antigen Antibody recognizes an antigen found on lymphoid cells. It reacts with B cells, T-cell subtypes, monocytes, macrophages, and is weakly expressed with granulocytes. The PD7/26 antibody was included in the 3rd International Workshop. CD45RB reacts with 3 of the 5 glycoproteins in the CD45 family (MW 190, 205 and 220 kDa). It is similar to CD45, except it is not expressed in Langerhan’s cells and a small subset of T cells.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

PD7/26

Isotype

IgG1/kappa

Antigen

CD45RB (Leukocyte Common Antigen)

Localization

Cell Membrane

Positive Control

Tonsil or lymphoma

1. Basadonna GP et al., Antibody-mediated targeting of CD45 isoforms: a novel immunotherapeutic strategy. Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3821-6.
2. Hart IJ, Schafer H, Scheper RJ, Stevenson GT. Subpopulations of guinea-pig T lymphocytes defined by isoforms of theleucocyte common antigen. Immunology 1992 Nov;77(3):377-84.
3. Kurtin PJ, Pinkus GS. Leukocyte common antigen—a diagnostic discriminant between hematopoietic and nonhematopoietic neoplasms in paraffin sections using monoclonal antibodies: correlation with immunologic studies and ultrastructural localization. Hum Pathol 1985 Apr;16(4):353-365.
4. Warnke RA, et al. Diagnosis of human lymphoma with monoclonal anti-leukocyte antibodies. N Encl J med 1983 Nov 24;309(21):1275-1281.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. National Committee for Clinical Laboratory Standards(NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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