Leukocyte Common Antigen (LCA) Cocktail

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Leukocyte Common Antigen (CD45RB) [PD7/26], catalog number PM091AA, is being discontinued. We will continue to offer this product until 06/30/16 or until current inventory is depleted, whichever occurs first.

Biocare Medical has Leukocyte Common Antigen (LCA) Cocktail (CM016, PM016, IP016) available as a substitute. This cocktail of PD7/26 and 2B11 antibody clones have been designated as CD45, which recognizes an antigen found on lymphoid cells.

The PD7/26/16 and 2B11 antibody clones have been designated as CD45. CD45 belongs to a leukocyte common antigen (LCA antibody) family of glycoproteins with molecular weights of 180, 190, 205 and 220 kDa. CD45 recognizes an antigen found on lymphoid cells. Studies have shown that most neoplastic B-cells and T-cells stain positively with CD45 in leukemia and in non-Hodgkin’s lymphomas; whereas most neoplastic myeloid and erythroid cells are negative. CD45 has also been observed to be unreactive with epithelium and connective tissues in published studies.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

PD7/26/16 and 2B11

Isotype

IgG1/kappa

Antigen

CD45 (Leukocyte Common Antigen)

Localization

Cell surface

Positive Control

Tonsil or lymphoma

1. Muzaffar S, et al. Immunophenotypic analysis of non-Hodgkin’s lymphoma. JPMA J Pak Med Assoc. 1997 Apr; 47(4):106-9.
2. Michels S, et al. Immunostaining for leukocyte common antigen using an Amplified avidin-biotin-peroxidase complex method and paraffin sections. A study of 735 hematopoietic and nonhematopoietic human neoplasms. Arch Pathol Lab Med. 1987 Nov; 111(11):1035-39.
3. Kurtin PJ, Pinkus GS. Leukocyte common antigen-a diagnostic discriminant between hematopoietic and nonhematopoietic neoplasms in paraffin sections using monoclonal antibodies: correlation with immunologic studies and ultrastructural localization. Hum Pathol. 1985 Apr; 16(4):353-65.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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