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Leukocyte Common Antigen (LCA) Cocktail
Leukocyte Common Antigen (CD45RB) [PD7/26], catalog number PM091AA, is being discontinued. We will continue to offer this product until 06/30/16 or until current inventory is depleted, whichever occurs first.
Biocare Medical has Leukocyte Common Antigen (LCA) Cocktail (CM016, PM016, IP016) available as a substitute. This cocktail of PD7/26 and 2B11 antibody clones have been designated as CD45, which recognizes an antigen found on lymphoid cells.
The PD7/26/16 and 2B11 antibody clones have been designated as CD45. CD45 belongs to a leukocyte common antigen (LCA antibody) family of glycoproteins with molecular weights of 180, 190, 205 and 220 kDa. CD45 recognizes an antigen found on lymphoid cells. Studies have shown that most neoplastic B-cells and T-cells stain positively with CD45 in leukemia and in non-Hodgkin’s lymphomas; whereas most neoplastic myeloid and erythroid cells are negative. CD45 has also been observed to be unreactive with epithelium and connective tissues in published studies.
PD7/26/16 and 2B11
CD45 (Leukocyte Common Antigen)
Tonsil or lymphoma
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3. Kurtin PJ, Pinkus GS. Leukocyte common antigen-a diagnostic discriminant between hematopoietic and nonhematopoietic neoplasms in paraffin sections using monoclonal antibodies: correlation with immunologic studies and ultrastructural localization. Hum Pathol. 1985 Apr; 16(4):353-65.
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5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.