L26 + CD3 antibodies allow B-cell and T-cell lymphomas to be identified on the same slide. L26 (CD20) reacts with the majority of B-cells present in peripheral blood and lymphoid tissues. In normal lymphoid tissue, L26 marks B-cells in germinal centers, particularly immunoblasts and rarely marks T-cells. This antibody has been shown to be a reliable pan B-cell marker. The rabbit monoclonal CD3 reacts with the intracytoplasmic portion of the CD3 antigen expressed by T-cells. CD3 stains human T-cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues.
Mouse Monoclonal, Rabbit Monoclonal
L26 + SP7
IgG2a + IgG
L26: B-cells , CD3: T-cells
L26: cytoplasmic (red), CD3: cytoplasmic (brown)
1. Nguyen DT, et al. Hematopathol Mol Hematol. 1996; 10(3):135-50.
2. Chadburn A, Knowles DM. Am J Clin Pathol. 1994 Sep; 102(3):284-91.
3. Davey FR, et al. Am J Pathol. 1987 Oct; 129(1):54-63.