Kappa + Lambda

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Kappa + Lambda antibody light chain counts and ratio may be useful in the identification of myelomas, plasmacytomas, and certain non-Hodgkin’s lymphomas. The most common feature of these malignancies is the restricted expression of a single light chain class. In normal tissue, the Kappa: Lambda cell ratio is approximately 2:1. While Kappa and Lambda antibodies may be assessed on two separate tissues, the double stain antibody allows the investigator to simultaneously see both Kappa and Lambda on the same tissue section, allowing the end-user a more accurate and easier assessment of the Kappa: Lambda ratio.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal, Rabbit Polyclonal

Clone

KDB-1 (kappa only)

Isotype

IgG1 (kappa only)

Antigen

Kappa and Lambda light chains

Localization

Kappa: cytoplasmic (brown), Lambda: cytoplasmic (red)

Positive Control

Tonsil

1. Samoszuk MK, et al. Diagn Immunol. 1985; 3(3):133-8.
2. Bray M, Alper MG. Am J Clin Pathol. 1983 Oct; 80(4):526-8.
3. Sobol RE, et al. Clin Immunol Immunopathol. 1982 Jul; 24(1):139-44.
4. Falini B, et al. J Histochem Cytochem. 1982 Jan; 30(1):21-6.
5. Marshall-Taylor CE, et al. Appl Immunohistochem Mol Morphol. 2002 Sep; 10(3):258-62.2004 Jan; 23(1):52-7.

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