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IGH rearrangements including translocations and fusions involving a variety of other genes is a common event. Numerous studies have shown that these rearrangements, with, for example MYC, MAF, CCND1 and MALT1 to be implicated in numerous hematological tumors including lymphomas, leukemia’s and multiple myeloma1,2,3,4.
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1. Amplification of IGH/CCND1 fusion gene in a primary plasma cell leukemia case. Ishigaki T, Sasaki K, Watanabe K, Nakamura N, Toyota S, Kobayashi H, Tohda S. Cancer Genet Cytogenet. 2010 Aug;201(1):62-5.
2. t(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Streubel B, Lamprecht A, Dierlamm J, Cerroni L, Stolte M, Ott G, Raderer M, Chott A. Blood 2003; 101: 2335-2339.
3. Long-range oncogenic activation of Igh–c-myc translocations by the Igh 3′ regulatory region. Monica Gostissa, Catherine T. Yan, Julia M. Bianco, Michel Cogné, Eric Pinaud & Frederick W. Alt. Nature 462, 803-807 (10 December 2009)
4. Fonseca et al. (2004). Genetics and cytogenetics of multiple myeloma: A workshop report. Cancer Res. 64:1546.
5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014