Human Chorionic Gonadotropin

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Human chorionic gonadotropin antibody (hCG) is a glycoprotein hormone synthesized in syncytiotrophoblastic cells of placenta and in certain trophoblastic tumors. The hormone-specific beta chains have molecular weights of 14 kDa and 17 kDa, respectively. It is believed that the C-terminal region of then CG-beta subunit plays a role in the intracellular behavior of the heterodimer. This antibody labels the cytoplasm of syncytiotrophoblastic cells and their tumors, as well as germ cell tumors of the ovaries, testes and extragonadal sites.

Intended Use

IVD

Species Reactivity

Human

Source

Rabbit Polyclonal

Clone

N/A

Isotype

N/A

Antigen

hGC protein

Localization

Cytoplasmic

Positive Control

Placenta

1. Weissbach L, Bussar-Maatz R, Mann K. The value of tumor markers in testicular seminomas. Results of a prospective multicenter study. Eur Urol. 1997;32(1):16-22.
2. Sheaff MT, et al. beta hCG as a prognostic marker in adenocarcinoma of the prostate. J Clin Pathol. 1996 Apr;49(4):329-32.
3. Matias-Guiu X, Prat J. Ovarian tumors with functioning stroma. An immunohistochemical study of 100 cases with human chorionic gonadotropin monoclonal and polyclonal antibodies. Cancer. 1990 May 1;65(9):2001-5.
4. Niehans GA, et al. Immunohistochemistry of germ cell and trophoblastic neoplasms. Cancer 1988 Sep 15;62 (6):1113-23.
5. Heshmati HM, et al. The immunocytochemical heterogeneity of silent pituitary adenomas. Acta Endocrinol (Copenh). 1988 Aug;118(4):533-7.
6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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