HMB45

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HMB45 antibody reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium (RPE) and melanoma cells. It is also thought to be oncofetal in nature and has been shown to label the majority of melanomas. Studies support the routine use of HMB45 (anti-gp100) as a sensitive and specific melanocytic marker.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

HMB45

Isotype

IgG1/kappa

Antigen

Melanoma

Localization

Cytoplasmic

Positive Control

Melanoma

1. Kapur RP, et al. Anti-melanoma monoclonal antibody HMB45 identified an oncofetal glycoconjugate associated with immature melanosomes. J. Histochem cytochem 1992; 40(2):207.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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