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HIF-1 alpha antibody has been shown to upregulate several genes to promote survival in hypoxic environments. Oxygen-breathing species express this highly-conserved transcriptional complex. There is evidence that tumor hypoxia promotes metastasis through the induction of MET overexpression by HIF-1 alpha. The mechanism of tumor hypoxia promoting metastasis remains uncertain. HIF-1 alpha is a key mediator of the cellular response to hypoxia and binds the MET promoter, resulting in increased expression of MET. In breast cancer, MET overexpression is associated with metastatic disease and poor prognosis.
1. This antibody contains less than 0.1% sodium azide. Concentrations less than 0.1% are not reportable hazardous materials according to U.S. 29 CFR 1910.1200, OSHA Hazard communication and EC Directive 91/155/EC. Sodium azide (NaN3) used as a preservative is toxic if ingested. Sodium azide may react with lead and copper plumbing to form highly explosive metal azides. Upon disposal, flush with large volumes of water to prevent azide build-up in plumbing. (Center for Disease Control, 1976, National Institute of Occupational Safety and Health, 1976) (4)
2. Specimens, before and after fixation, and all materials exposed to them should be handled as if capable of transmitting infection and disposed of with proper precautions. Never pipette reagents by mouth and avoid contacting the skin and mucous membranes with reagents and specimens. If reagents or specimens come in contact with sensitive areas, wash with copious amounts of water. (5)
3. Microbial contamination of reagents may result in an increase in nonspecific staining.
4. Incubation times or temperatures other than those specified may give erroneous results. The user must validate any such change.
5. Do not use reagent after the expiration date printed on the vial.
6. The MSDS is available upon request and is located at http://biocare. net/support/msds/.