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Epidermal Growth Factor Receptor antibody [H11] reacts with a 170kDa (wild type) and 145kDa (vIII variant) protein, identified as the first member of type I family of growth factor receptors (initially identified as EGR-Receptor). The EGFR antibody H11 clone shows no cross reactivity with c-erbB-2, cerbB-3 or c-erbB-4. Various studies have observed and reported over-expression of EGFR in tumors of breast (25%), brain, bladder, lung, gastric, esophagus, cervix, ovary and endometrium.
Cell membrane and some cytoplasmic
Squamous cell carcinoma or skin
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