E-cadherin

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E-cadherin is a transmembrane glycoprotein that mediates epithelial cell-to-cell adhesion. The loss of E-cadherin can result in the disruption of cell clusters. It has been postulated in literature that E-cadherin may function as a tumor suppressor protein. Several studies have associated the loss of E-cadherin with metastasis and poor prognosis in invasive breast cancer. Additional studies have suggested that E-cadherin can help differentiate between ductal and lobular neoplasms of the breast. E-cadherin immunostaining has also been shown to be an independent predictor of disease progression in bladder cancer.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

HECD-1

Isotype

IgG1

Antigen

E-cadherin

Localization

Cytoplasmic/membrane

Positive Control

Breast cancer

1. Yoshida R, et al. Int J Oncol. 2001 Mar; 18(3):513-20.
2. Byrne RR, et al. J Urol. 2001 May; 165(5):1473-9.
3. Acs G, et al. Am J Clin Pathol. 2001 Jan; 115(1):85-98.

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