E-cadherin

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E-cadherin is a transmembrane glycoprotein that mediates epithelial cell-to-cell adhesion. The loss of E-cadherin can result in the disruption of cell clusters. It has been postulated in literature that E-cadherin may function as a tumor suppressor protein. Several studies have associated the loss of E-cadherin with metastasis and poor prognosis in invasive breast cancer. Additional studies have suggested that E-cadherin can help differentiate between ductal and lobular neoplasms of the breast. E-cadherin immunostaining has also been shown to be an independent predictor of disease progression in bladder cancer.

Intended Use

IVD

Species Reactivity

Human, Others Not Tested

Source

Mouse Monoclonal

Clone

HECD-1

Isotype

IgG1

Antigen

E-cadherin

Localization

Cytoplasmic/membrane

Positive Control

Breast cancer

1. Yoshida R, et al. Int J Oncol. 2001 Mar; 18(3):513-20.
2. Byrne RR, et al. J Urol. 2001 May; 165(5):1473-9.
3. Acs G, et al. Am J Clin Pathol. 2001 Jan; 115(1):85-98.

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