DOG1

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DOG1 antibody expression has been reported to be a very sensitive and specific marker for gastrointestinal stromal tumor (GIST) cells. In studies of GIST cases with KIT mutations, DOG1 detected 11% more cases than CD117. As a result of its localization in the cell membrane, its absence in the majority of normal tissue and its presence in most GIST tissue, recent studies suggest that DOG1 may be a helpful target to aid in the diagnosis and assignment of appropriate treatment of GIST. DOG1 expression is seen in fewer cases of mesenchymal and epithelial tumors, seminomas and melanomas when compared with CD117.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

DOG1.1

Isotype

IgG1/K

Antigen

Synthetic peptide of human DOG1

Localization

Membrane & Cytoplasm

Positive Control

Gastrointestinal stromal tumors

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

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1. Espinosa I, et al. Am J Surg Pathol. 2008 Feb; 32(2):210-8.
2. Miwa S, et al. J Gastroenterol. 2008; 43(7):531-7.
3. Parfitt JR, et al. Histopathology. 2008 Jun; 52(7):816-23.
4. West RB, et al. Am J Pathol. 2004 Jul; 165(1):107-13.

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