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This MAb [D33] recognizes desmin antibody, a 53kDa intermediate filament (IF) protein. Studies have shown that [D33] is highly specific to desmin and shows no cross-reaction with other IF proteins. Studies have also shown D33 to be useful in identification of tumors of myogenic origin; it has been shown to react with leiomyosarcomas (smooth muscle) as well as rhabdomyosarcomas (striated muscle). Several studies have utilized desmin in a panel to aid in the classification of uterine sarcomas. Studies addressing desmoplastic reaction in colorectal and pancreatic cancers have demonstrated D33 to be a helpful marker of tumor invasion.
Human, Mouse, Rat
Leiomyoma, leiomyosarcoma, rhabdomyosarcoma
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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.
1. Robin YM, et al. Mod Pathol. 2013 Apr; 26(4):502-10.
2. Abeler VM, et al. Int J Gynecol Pathol. 2011 May; 30(3):236-43.
3. Ohno K, et al. Int J Mol Sci. 2013 Jun; 14(7):13129-36.
4. Apte MV, et al. Pancreas. 2004 Oct; 29(3):179-87.