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D2-40 is a new selective marker of lymphatic endothelium in normal tissues and vascular lesions. In recent studies, clone D2-40 has shown a staining reaction in lymphatic channel endothelium, but not in the adjacent capillary. D2-40 has been widely used for tumor lymphangiogenesis and lymphatic vessel invasion in human cancers. The Ki-67 nuclear antigen is associated with cell proliferation and is used to grade proliferation rates of tumors. The Multiplex IHC stain D2-40 and Ki-67 can be used to detect relative lymph vessel area, lymph vessel perimeters, and simultaneously used to calculate cell proliferation rates in tumors, thus is useful in the indentification of aggressive types of cancer and their potential metastasis.
Mouse Monoclonal, Rabbit Monoclonal
D2-40 + SP6
D2-40 + Ki-67
D2-40 (Cytoplasm/lymphatic epithelium): Red Ki-67 (Nuclear): Brown
Colon or tonsil
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2. Cassarino DS, et al. Arch Dermatol. 2008 Jan; 144(1):49-56.
3. Fernández MI, et al. Eur Urol. 2008 Mar; 53(3):571-8.