D2-40 + Ki-67

SKU: 399, ki67 Categories: , ,

D2-40 is a new selective marker of lymphatic endothelium in normal tissues and vascular lesions. In recent studies, clone D2-40 has shown a staining reaction in lymphatic channel endothelium, but not in the adjacent capillary. D2-40 has been widely used for tumor lymphangiogenesis and lymphatic vessel invasion in human cancers. The Ki-67 nuclear antigen is associated with cell proliferation and is used to grade proliferation rates of tumors. The Multiplex IHC stain D2-40 and Ki-67 can be used to detect relative lymph vessel area, lymph vessel perimeters, and simultaneously used to calculate cell proliferation rates in tumors, thus is useful in the indentification of aggressive types of cancer and their potential metastasis.

Intended Use


Species Reactivity



Mouse Monoclonal, Rabbit Monoclonal


D2-40 + SP6


IgG1, IgG


D2-40 + Ki-67


D2-40 (Cytoplasm/lymphatic epithelium): Red Ki-67 (Nuclear): Brown

Positive Control

Colon or tonsil

By Letter


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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Kadota K, et al. Lung Cancer. 2010 Oct; 70(1):88-93.
2. Cassarino DS, et al. Arch Dermatol. 2008 Jan; 144(1):49-56.
3. Fernández MI, et al. Eur Urol. 2008 Mar; 53(3):571-8.


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