D2-40 + CK8/18

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D2-40 reacts with an O-linked sialoglycoprotein (MW 40 kDa) found in lymphatic endothelium, fetal testis and on the surface of testicular germ-cell tumors. D2-40 is a new selective marker of lymphatic endothelium in normal tissues and vascular lesions. In recent studies, clone D2-40 has shown a staining reaction in lymphatic channel endothelium, but not in the adjacent capillaries. Cytokeratin 8/18 (CK8/18) are type-II Intermediate Filament proteins that are found in many simple epithelial cells in respiratory, gastrointestinal, thyroid, and male and female reproductive tracts. In immunohistochemistry, CK8/18 has also been shown to stain most carcinomas such as liver, prostate, pancreatic, lung, breast and colon cancers. By labeling lymphatic endothelium with D2-40 (DAB) and carcinomas with CK8/18 (Warp Red), the staining contrast in a single section may simplify the evaluation and assessment of lymphatic micro-invasion.

Intended Use



D2-40, EP17, EP30


Brown (DAB), Red (Warp Red), Red (Warp Red)


IgG, IgG1


CK18, CK8, O-linked sialoglycoprotein


Cystoplasmic, Cystoplasmic lymphatic endothelium, Cytoplasmic

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

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