D2-40 + CD31

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SKU: 3021DS Categories: , ,

D2-40 is a selective marker of lymphatic endothelium in normal tissues and vascular lesions. According to studies, D2-40 effectively marked the lymphatic channel endothelium, but not the adjacent capillary. CD31, also known as PECAM-1, is a 130 kDa integral membrane glycoprotein found on the surface of endothelial cells, platelets and some hematopoietic cells. The CD31 antibody also labels endothelial cells of arteries, arterioles, venules, veins, and non-sinusoidal capillaries in various tissues. CD31 has been shown to be one of the most sensitive and specific endothelial cell markers. In addition, CD31 has been used to evaluate vascular invasion of tumors and assess angiogenesis. The combination of D2-40 and CD31 can serve as a co-marker for both lymphatic density and blood vascular studies.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal, Rabbit Monoclonal

Clone

D2-40 (D2-40) + EP78 (CD31)

Isotype

IgG1 (D2-40) + IgG (CD31)

Antigen

O-linked sialoglycoprotein (D2-40) + a synthetic peptide derived from human CD31

Localization

D2-40 (Cytoplasmic, lymphatic epithelium): Brown with MACH 2 Double Stain 2 or Red with MACH 2 Double Stain 1. CD31 (Cytoplasmic/membrane): Red with MACH 2 Double Stain 2 or Brown MACH 2 Double Stain

Download DS Data Sheet
Download RUO Data Sheet for International
Download SDS Sheet

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Kahn HJ, Marks A. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest. 2002 Sep;82(9):1255-7.
2. Engel CJ, et al. Tumor angiogenesis predicts recurrence in invasive colorectal cancer when controlled for Dukes staging. Am J Surg Pathol. 1996 Oct;20(10):1260-5.
3. El-Gohary YM, et al. Significance of periductal lymphatic and blood vascular densities in intraductal carcinoma of the breast. Breast J. 2009 May-Jun;15(3):261-7.
4. Saad RS, et al. Lymphatic vessel density as a prognostic marker in clinical stage I endocervical adenocarcinoma. Int J Gynecol Pathol. 2010 Jul;29(4):386-93.
5. El-Gohary YM, et al. Prognostic significance of intratumoral and peritumoral lymphatic density and blood vessel density in invasive breast carcinomas. Am J Clin Pathol. 2008 Apr;129(4):578-86.
6. Renyi-Vamos F, et al. Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer. Clin Cancer Res. 2005 Oct 15;11(20):7344-53.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
8. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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