D2-40 (Lymphatic Marker)

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D2-40 antibody is a selective marker of lymphatic endothelium in normal tissues and vascular lesions. Studies have shown [D2-40] staining in lymphatic channel endothelium, but not in the adjacent capillary. In the same study, D2-40 stained endothelium of lymphangiomas; whereas hemangiomas, glomus tumors, angiolipomas, pyogenic granulomas and vascular malformations were negative for staining. D2-40 has also been shown to react with Kaposi’s sarcoma and a subset of angiosarcomas. Studies indicate that D2-40 may be a very specific marker for malignant mesothelioma.

Intended Use

IVD

Species Reactivity

Human, Mouse, Rat

Source

Mouse Monoclonal

Clone

D2-40

Isotype

IgG1

Antigen

0-linked sialoglycoprotein

Localization

Cytoplasm (lymphatic epithelium)

Positive Control

Breast or colon cancer

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

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1. Kahn HJ, et al. Lab Invest. 2002 Sep; 82(9):1255-7.
2. Chu AY, et al. Mod Pathol. 2005 Jan; 18(1):105-10.
3. Rao P, et al. Am J Dermatopathol. 2013 Jun; 35(4):432-7.
4. Kao SC, et al. Pathology. 2011 Jun; 43(4):313-7.

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