Cytokeratin 7

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Cytokeratin 7 antibody is an intermediate filament protein (IFP) of 54 kDa that recognizes the simple epithelium found in most glandular and transitional epithelia; but is not found in the stratified squamous epithelia. This rabbit monoclonal antibody [BC1] has been shown to be highly specific to Cytokeratin 7 and shows no cross-reaction with other IFPs. Cytokeratin 7 is expressed in epithelial cells of ovary, lung and breast. It is often used in conjunction with Cytokeratin 20 and CDX-2 to aid in distinguishing pulmonary, ovarian and breast carcinomas (CK7+) from most colon carcinomas (CK7-).

Intended Use

IVD

Species Reactivity

Human

Source

Rabbit Monoclonal

Clone

BC1, Biocare Clone

Isotype

IgG

Antigen

CK7

Localization

Cytoplasmic

Positive Control

Breast, lung or ovarian cancers

1. Qi W, et al. Appl Immunohistochem Mol Morphol. 2009 May; 17(3):233-8.
2. Ross DS, et al. Am J Clin Pathol. 2013 Jan; 139(1):62-70.
3. McCluggage WG, Young RH. Semin Diagn Pathol. 2005 Feb; 22(1):3-32.
4. Sousa V, et al. Virchows Arch. 2011 May; 458(5):571-81.

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