Cytokeratin LMW (8/18)

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Cytokeratin LMW (8/18) antibody [5D3] recognizes Cytokeratins (CK) 8 and 18 intermediate filament proteins. In normal tissues, [5D3] recognizes all simple and glandular epithelium. In neoplastic tissues, [5D3] may prove useful to aid in the identification of adenocarcinomas and some squamous cell carcinomas. It is generally negative in keratinizing squamous carcinomas. Studies suggest [5D3] can be used in conjunction with HMW CK to rule out squamous cell carcinoma. Studies have also shown CK 8/18 expression in squamous cell carcinomas of the oral cavity may indicate a decreased survival rate.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

5D3

Isotype

IgG1

Antigen

CK 8/18 (LMW)

Localization

Cytoplasmic

Positive Control

Skin

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3. Rattan B, et al. J Clin Diagn Res. 2012 Nov; 6(9):1495-8.
4. Fillies T, et al. BMC Cancer. 2006 Jan; 6:10.
5. Reisenbichler ES, et al. Mod Pathol. 2011 Feb; 24(2):185-93.
6. Wang Y, et al. Diagn Pathol. 2013 Jan 18; 8:8.

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