Cytokeratin 5 (CK5)

$146.00$335.00

Clear
SKU: 430 Categories: ,

Cytokeratin 5 antibody rabbit is a type II intermediate filament protein that is expressed in active basal layers of most stratified squamous epithelia. CK5 is expressed in many non-keratinizing stratified squamous epithelia as well as basal cells in prostate glands and myoepithelial cells in mammary glands. In a published study, rabbit monoclonal CK5 antibody was compared to mouse monoclonal CK5/6. CK5 was 84% sensitive and 100% specific for lung SqCC when compared to CK5/6 (80% sensitivity and 97% specificity). The CK5 predilute has been optimized for lung squamous cell carcinoma; other tumors have not been tested.

Intended Use

IVD

Species Reactivity

Human

Source

Rabbit Monoclonal

Clone

EP42

Isotype

N/A

Antigen

C-terminal region of human CK5

Localization

Cytoplasmic

Positive Control

Lung squamous cell carcinoma, some breast cancers, or normal prostate or skin

Download DS Data Sheet
Download RUO Data Sheet for International
Download SDS Sheet

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Mukhopadhyay S, Katzenstein AL. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, Napsin A, p63, and CK5/6. Am J Surg Pathol. 2011 Jan; 35(1):15-25.
2. Tacha D, Yu C, Haas T. TTF-1, Napsin A, p63, TRIM29, Desmoglein-3 and CK5: An Evaluation of Sensitivity and Specificity and Correlation of Tumor Grade for Lung Squamous Cell Carcinoma vs. Lung Adenocarcinoma. Modern Pathology; USCAP, 2011 (Abstract Accepted)
3. Tacha D, Zhou D, Henshall-Powell RL¹. Distinguishing Adenocarcinoma from Squamous Cell Carcinoma in Lung Using Double Stains p63+ CK5 and TTF-1 + Napsin A. Modern Pathology; Pathology Volume 23, Supplement 1, Feb 2010; Abstract 1852, page 222A.
4. Terry J, et al. Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples. Am J Surg Pathol. 2010 Dec; 34(12):1805-11.
5. Kargi A, Gurel D, Tuna B. The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas. Appl Immunohistochem Mol Morphol. 2007 Dec; 15(4):415-20.
6. Miettinen M, Sarlomo-Rikala M. Expression of calretinin, thrombomodulin, keratin
5, and mesothelin in lung carcinomas of different types: an immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleura. Am J Surg Pathol. 2003 Feb; 27(2):150-8.
7. Bocker W, et al. Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab Invest. 2002 Jun; 82 (6):737-46.
8. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
9. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005

Reviews


There are no reviews yet.

Be the first to review “Cytokeratin 5 (CK5)”