Cytokeratin 20

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Cytokeratin 20 antibody is an intermediate filament protein that is expressed in adenocarcinomas of the colon, stomach, pancreas, bile system and mucinous ovarian tumors, transitional cell carcinomas of the urinary tract, and Merkel cell carcinomas. CK20 is essentially non-reactive in squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, as well as non-mucinous tumors of the ovary and small cell carcinomas. Cytokeratin 20 is often used in conjunction with CK7 and other antibodies in distinguishing colon carcinomas (CK20+) from ovarian, pulmonary, and breast carcinomas.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

Ks20.8

Isotype

IgG2a

Antigen

CK20

Localization

Cytoplasmic

Positive Control

Colon Carcinoma

1. Perry A, Parisi JE, Kurtin PJ. Hum Pathol. 1997 Aug; (8):938-43.
2. Sack MJ, Roberts SA. Diagn Cytopathol. 1997 Feb; 16(2):132-6.
3. Moll R, et al. Am J Pathol. 1992 Feb; 140(2):427-47.

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