Cytokeratin 19

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Cytokeratin 19 antibody reacts with the rod domain of human keratin 19, a 40kDa polypeptide. The antibody reacts with MCF-7 cells and has been shown to label trichoblastoma, thyroid tumors, oral cancer, and epithelial odontogenic tumors. CK19 is not expressed in most hepatocytes, therefore cytokeratin 19 is useful in the identification of liver metastasis and can be used in a panel with Hepatocyte Specific Antigen (HepPar1).

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

Ks19.1

Isotype

IgG2a/κ

Antigen

CK19

Localization

Cytoplasmic

Positive Control

Colon Ca, Skin

1. Rorive S, et al. Changes in galectin-7 and cytokeratin 19 expression during the progression of malignancy in thyroid tumors: diagonostic and biological implications. Mod Pathol. 2002 Dec;15(12):1294-301.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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