Cyclin D1 Rabbit

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This rabbit monoclonal antibody recognizes a protein of 36 kDa, identified as Cyclin D1 antibody rabbit (also known as Bcl-1 or PRAD-1). Cyclin D1 antibody rabbit is a regulatory subunit of certain protein kinases thought to advance the G1 phase of the cell cycle. Cyclin D1, when used in tandem with CD5, CD10 and CD23, is a reliable immunohistochemical marker for the mantle cell lymphoma. Studies have shown that Cyclin D1 is a clinical informative marker for invasive breast cancer. Due to the superior technology in the development of this antibody, its binding capacity exceeds mouse monoclonal antibodies and is virtually background free.

Intended Use

IVD

Species Reactivity

Human, Mouse, Rat

Source

Rabbit Monoclonal

Clone

SP4

Isotype

IgG

Antigen

Cyclin D1

Localization

Nuclear

Positive Control

Mantle cell lymphoma and breast cancer

1. Pruneri G, et al. Appl Immunohistochem Mol Morphol. 2005 Dec; 13(4):318-22.
2. Shakir R, Ngo N, Naresh KN. J Clin Pathol. 2008 Aug; 61(8):920-7.
3. Lee A, et al. Jpn J Clin Oncol. 2007 Sep; 37(9):708-14.
4. Mylona E, et al. Histopathology. 2013 Feb; 62(3):472-80.

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