COX-2

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Cyclooxygenase (COX-2) is an inducible enzyme involved in production of prostaglandins in inflammatory processes. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX-2 is therefore of interest in studying immune response regulation. COX-2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. There is now increasing evidence that a constitutive expression of COX-2 plays a role in development and progression of malignant epithelial tumors. In studies, COX-2 positivity retained independent roles in predicting a poor chance of response to treatment. COX-2 positive patients had a shorter overall survival rate than COX-2 negative patients.

Intended Use

IVD

Species Reactivity

Human, Mouse, Rat

Source

Rabbit Monoclonal

Clone

SP21

Isotype

IgG

Antigen

Cyclooxygenase-2

Localization

Cytoplasmic

Positive Control

Breast, colon or lung carcinoma

1. Peng L, et al. PLoS One. 2013; 8(3):e58891. Epub 2013 Mar 20.
2. Pan J, et al. Head Neck. 2012 Sep 13. [Epub ahead of print].
3. Laga AC, Zander DS, Cagle PT. Arch Pathol Lab Med. 2005 Sep; 129(9):1113-7.
4. Soumaoro LT, et al. Clin Cancer Res. 2004 Dec; 10(24):8465-71.
5. Wang W, Bergh A, Damber JE. Prostate. 2004 Sep; 61(1):60-72.
6. Boland GP, et al. Br J Cancer. 2004 Jan; 90(2):423-9.

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