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Copy control probes are suggested for use to ensure that the chromosome of interest is actually being tagged thus enabling accurate interpretation of any change in signal from a relevant locus specific probe that may be being used in conjunction1. Studies have shown it to be of value in combination with MDM2. Due to amplification of the respective chromosomal region, MDM2 is over expressed in many human tumors such as soft tissue sarcomas, osteosarcomas2, gliomas, NSCLC, gastric and breast carcinomas.
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1. Guidance for Fluorescence in Situ Hybridization Testing in Hematologic Disorders. Daynna J. Wolff, Adam Bagg, Linda D. Cooley, Gordon W. Dewald, Betsy A. Hirsch, Peter B. Jacky, Kathleen W. Rao, P. Nagesh Rao. J Mol Diagn. 2007 Apr; 9(2): 134–143.
2. The E3 ubiquitin protein ligase MDM2 dictates all-trans retinoic
acid-induced osteoblastic differentiation of osteosarcoma cells by modulating the degradation of RARα. M Ying, L Zhang, Q Zhou, X Shao, J Cao, N Zhang, W Li, H Zhu, B Yang and Q He. Oncogene , (18 January 2016)
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.