Cytokeratin 7 (CK7)

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CK7 antibody is an intermediate filament protein (IFP) of 54 kDa that recognizes the simple epithelium found in most glandular and transitional epithelia; but not in stratified squamous epithelia. This monoclonal antibody [OV-TL 12/30] has been shown to be highly specific to Cytokeratin 7 and shows no cross-reaction with other IFPs. Cytokeratin 7 is a basic cytokeratin and is expressed in epithelial cells of ovary, lung and breast, but not of colon or gastrointestinal tract. It is often used in concert with Cytokeratin 20 and CDX-2 to aid in distinguishing ovarian, pulmonary and breast carcinomas (CK7+) from colon carcinomas (CK7-).

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

OV-TL 12/30

Isotype

IgG1

Antigen

CK7

Localization

Cytoplasmic

Positive Control

Ovarian or breast cancer

1. Tot T. Eur J Cancer. 2002 Apr; 38(6):758-63.
2. Lagendijk JH, et al. Hum Pathol. 1998 May; 29(5):491-7.
3. Tan J, et al. Hum Pathol. 1998 Apr; 29(4):390-6.
4. Bouwens L. J Pathol. 1998 Mar; 184(3):234-9.
5. Loy TS, Calaluce RD, Keeney GL. Mod Pathol. 1996 Nov; 9(11):1040-4.
6. Wauters CC, et al. Hum Pathol. 1995 Aug; 26(8):852-5.
7. Loy TS, Calaluce RD. Am J Clin Pathol. 1994 Dec; 102(6):764-7.

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