CK5/14 + p63 + P504S

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Clear

In prostate tissue, mRNA for CK5 and CK14 has been detected in the basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; however, expression of CK5 or CK14 was not identified in invasive prostatic adenocarcinoma. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. In IHC, P504S has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN have been found to express P504S, whereas P504S was nearly undetectable in benign glands.

Formerly known as PIN-4®

Intended Use

RUO

Source

Mouse Monoclonal, Mouse Monoclonal, Mouse Monoclonal, Rabbit Polyclonal

Isotype

IgG, IgG1/kappa, IgG2a/kappa, IgG3

Antigen

CK14, CK5, P504S, p63

Localization

Cytoplasmic, Granular cytoplasm, Nuclear

Staining

Brown (DAB), Brown (DAB), Brown (DAB), Red (Warp Red)

1. Tacha DE, Miller RT. Appl Immunohistochem Mol Morphol. 2004 Mar; 12(1):75-8.
2. Tacha DE, et al. Mod Pathol. 2009 Jan; 22(Supplement 1s):388A.
3. Signoretti S, et al. Am J Pathol. 2000 Dec; 157(6):1769-75.
4. Beach R, et al. Am J Surg Pathol. 2002 Dec; 26(12):1588-96.
5. Luo J, et al. Cancer Res. 2002 Apr 15; 62(8):2220-6.
6. Wang Y, et al. Differentiation. 2001 Oct; 68(4-5):270-9.
7. Tokar EJ, et al. Differentiation. 2005 Dec; 73(9-10):463-73.
8. Collins AT, et al. J Cell Sci. 2001 Nov; 114(Pt 21):3865-72.

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