CK5 + p63

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Cytokeratin 5 is a 58-kDa protein found in many non-keratinizing, stratified squamous epithelia such as tongue mucosa, basal epithelia hair follicles, trachea, as well as basal cells in prostate and mammary glands. CK5 is also expressed in most epithelial and biphasic mesotheliomas. p63 is detected in prostatic basal cells in normal prostate; however, it is negative in malignant tumors of the prostate gland. Thus, p63 may be useful to aid in the differentiation of benign and malignant tumors of prostate gland. It has been reported that p63 may be useful as a negative marker for malignant mesotheliomas. p63 also stains basal cells in mammary glands.

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

XM26 + BC4A4

Isotype

IgG1 and IgG2a

Antigen

Cytokeratin 5 + p63

Localization

CK5: Myoepithelium or luminal. p63: Nuclear

Positive Control

Normal breast or ductal cell carcinoma

1. Abrahams NA, Ormsby AH, Brainard J. Histopathology. 2002 Jul; 41(1):35-41.
2. Khilko N, et al. Breast Cancer (Auckl). 2010 Oct; 4:49-55.
3. Zhou M, et al. Am J Surg Pathol. 2003 Mar; 27(3):365-71.
4. Browne TJ, et al. Hum Pathol. 2004 Dec; 35(12):1462-8.
5. Hameed O, Humphrey PA. Semin Diagn Pathol. 2005 Feb; 22(1):88-104.
6. Douglas-Jones A, et al. Histopathology. 2005 Aug; 47(2):202-8.

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