CD61

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Due to an unexpected discontinuation of CD61 from our source vendor, we will have to put our CD61 on backorder until a suitable replacement source can be found. To ensure a high quality replacement material, this process will take us at least until May. There is also the possibility that we may not be able to locate a secondary source and be forced to discontinue this product. We apologize for this inconvenience and thank you for your understanding.

The CD61 antigen, also known as GPIIIa, is a glycoprotein of 105 kD and has been shown to be expressed in myeloid cells, monocytes, endothelial cells, smooth muscle cells, macrophages and platelets (1-6). CD61 has been shown to be useful in evaluating megakaryocytopoiesis as it relates to myelodysplastic disorders, acute myeloid leukemias and acute megakaryoblastic leukemias (2,3). Immunohistochemistry with CD61 has also been useful in identifying platelet adhesion in advanced atherosclerosis and was helpful in identifying fat embolism in pulmonary tissue (4,5). The identification of CD61 expression in patients with insudative platelet arteriolopathy helped facilitate recognition of vascular calcineurin inhibitor toxicity in renal allograft biopsies (6).

Format

Concentrate, Predilute

Intended Use

IVD

Source

Mouse Monoclonal

Clone

2f2

Isotype

IgG1

Antigen

Recombinant protein encoding part of the external domain of human CD61

Localization

Cell membrane / cytoplasm

Positive Control

Bone marrow

Species Reactivity

Human; others not tested

1. Jiménez-Marín A, et al. Molecular characterization and expression analysis of the gene coding for the porcine beta(3) integrin subunit (CD61). Gene. 2008 Jan 31; 408(1-2):9-17.
2. Fox SB, et al. Megakaryocytes in myelodysplasia: an immunohistochemical study on bone marrow trephines. Histopathology. 1990 Jul; 17(1):69-74.
3. Thiele J, et al. Atypical micromegakaryocytes, promegakaryoblasts and megakaryoblasts: a critical evaluation by immunohistochemistry, cytochemistry and morphometry of bone marrow trephines in chronic myeloid leukemia and myelodysplastic syndromes. Virchows Arch B Cell Pathol Incl Mol Pathol. 1992; 62 (5):275-82.
4. Gonzalez J, et al. High fat diet induces adhesion of platelets to endothelium in two models of dyslipidemia. J Obes. 2014; 2014:591270.
5. Neri M, et al. CD61 and fibrinogen immunohistochemical study to improve the postmortem diagnosis in a fat embolism syndrome clinically demonstrated by transesophageal echocardiography. Forensic Sci Int. 2010 Oct 10; 202(1-3):e13-7.
6. Meehan SM, et al. Platelet CD61 expression in vascular calcineurin inhibitor toxicity of renal allografts. Hum Pathol. 2008 Apr; 39(4):550-6.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
8. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.