CD57 (Natural Killer Cell)

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CD57 antibody [NK-1] marks a subset of lymphocytes known as natural killer (NK) cells. Follicular center cell lymphomas often contain many NK cells within the neoplastic follicles. Studies have shown that CD57 expression is present in normal and neoplastic pituitaries. It has been reported that CD57 reactivity may be used as an additional immunophenotypic criterion in distinguishing nodular lymphocyte predominance Hodgkin’s disease from nodular sclerosing Hodgkin’s disease, T-cell-rich B-cell lymphoma, and follicular lymphoma. CD57 [NK-1] also reportedly stains neuroendocrine cells and their respective tumors.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

NK-1

Isotype

IgM/kappa

Antigen

CD57

Localization

Cell membrane in germinal centers of lymph nodes or tonsils

Positive Control

Single tonsil

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1. Sanno N, et al. J Neurooncol. 1997 Oct; 35(1):29-38. 2. Papadimitriou CS, et al. Leuk Lymphoma. 1995 Dec; 20(1-2):125-30. 3. Atochina OV, et al. Tsitologiia. 1994; 36(9-10):1006-11. 4. Liu XH, et al. Hinyokika Kiyo. 1993 May; 39(5):439-44. 5. Kamel OW, et al. Am J Pathol. 1993 Feb; 142(2):541-6. 6. Ghali VS, Jimenez EJ, Garcia RL. Hum Pathol. 1992 Jan; 23(1):21-5.

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