CD4 (M) + CD8 (RM)

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CD4, a T-cell subset found in thymocytes and peripheral blood lymphocytes, is expressed in the majority of T-cell lymphomas. CD8 is a T-cell subset found in cortical thymocytes, T-cells and NK cells. The CD4:CD8 ratio may be helpful in distinguishing mycosis fungoides from its inflammatory mimics or as an aid in determining clinical outcome in cervical carcinoma. It was reported that CD4 and CD8 expression in gastric mucosal of HIV-infected individuals is closely correlated with disease progression. This Multiplex IHC allows ratios and/or cell counts to be done on a single slide.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal, Rabbit Monoclonal

Clone

BC/1F6 +SP16

Isotype

IgG1, IgG

Antigen

CD4+CD8

Localization

CD4: (Cell surface/membrane): Brown CD8: (Cell surface): Red

Positive Control

Tonsil or mycois fungoides

1. Boone SL, et al. G Ital Dermatol Venereol. 2008 Dec; 143(6):409-14. 2. Hodak E, et al. J Am Acad Dermatol. 2006 Aug; 55(2):276-84. 3. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Aug; 23(4):261-4. 4. Tirumalae R, Panjwani PK. Indian J Dermatol. 2012 Nov; 57(6):424-7. 5. Shah W, et al. Cell Mol Immunol. 2011 Jan; 8(1):59-66.

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