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CD3 is expressed throughout the T-cell differentiation process. CD3 is a highly specific and sensitive T-cell lineage marker, making it ideal for the immunohistochemical analysis of lymphohematologic malignancies. Notable exceptions include some of the more aggressive large T-cell lymphomas and CD30 (Ki-1) positive anaplastic large cell lymphomas, which may not express detectable antigen (1-3). A monoclonal antibody to human CD3 is regarded as a reliable pan T-cell antibody used in identifying lymphomas and lymphocytic colitis in paraffin sections (4).
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1. Campana D, et al. The cytoplasmic expression of CD3 antigens in normal and malignant cells of the T lymphoid lineage. J Immunol. 1987 Jan; 138(2):648-55.
2. Cabeçadas JM, Isaacson PG. Phenotyping of T-cell lymphomas in paraffin sectionswhich antibodies? Histopathology. 1991 Nov; 19(5):419-24.
3. Steward M, et al. Production and characterization of a new monoclonal antibody effective in recognizing the CD3 T-cell associated antigen in formalin-fixed embedded tissue. Histopathology. 1997 Jan; 30(1):16-22.
4. “CD3 Assessment Run 37 2013.” NordiQC. NordiQC, 04 Dec. 2013. Web. 16 June 2015.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.