CD3

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This rabbit monoclonal antibody reacts with the intracytoplasmic portion of the CD3 antibody antigen expressed by T cells. Studies have shown that CD3 stains human T-cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. It does not react with B-cells, monocytes, granulocytes and platelets. CD3 is regarded as a reliable pan T-cell antibody used in the immunophenotyping of T-cell lymphomas in paraffin sections with the majority of T-cell lymphomas expressing positivity for CD3. When used in conjunction, CD3 and UCHL-1 together identified the vast majority of T-cell lymphomas in paraffin sections.

Intended Use

IVD

Species Reactivity

Human

Source

Rabbit Monoclonal

Clone

EP41

Isotype

IgG

Antigen

CD3 (T-Cell)

Localization

Predominantly cell membrane and some cytoplasmic

Positive Control

Tonsil or T-cell lymphoma

Download Data Sheet
Download RUO Data Sheet for International
Download SDS Sheet

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Rossi S, et al. Am J Clin Pathol. 2005 Aug; 124(2):295-302.
2. Cabecadas JM, Isaacson PG. Histopathology. 1991 Nov; 19(5):419-24.
3. Steward M, et al. Histopathology. 1997 Jan; 30(1):16-22.

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