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This rabbit monoclonal antibody reacts with the intracytoplasmic portion of the CD3 antibody antigen expressed by T cells. Studies have shown that CD3 stains human T-cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. It does not react with B-cells, monocytes, granulocytes and platelets. CD3 is regarded as a reliable pan T-cell antibody used in the immunophenotyping of T-cell lymphomas in paraffin sections with the majority of T-cell lymphomas expressing positivity for CD3. When used in conjunction, CD3 and UCHL-1 together identified the vast majority of T-cell lymphomas in paraffin sections.
Predominantly cell membrane and some cytoplasmic
Tonsil or T-cell lymphoma
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1. Rossi S, et al. Am J Clin Pathol. 2005 Aug; 124(2):295-302.
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3. Steward M, et al. Histopathology. 1997 Jan; 30(1):16-22.