CD163

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CD163 antibody aids in identifying cells of monocyte/macrophage lineage in normal and neoplastic conditions. This antibody reacts with human scavenger receptor cysteine-rich protein CD163 (p155, M130) found on mononuclear phagocytes including human monocytes and macrophages. Compared with the CD68 antibodies, studies have shown that CD163 demonstrated greater specificity as a marker of disorders of monocyte/macrophage origin. However, immunohistochemical evaluation of CD163 expression does not seem to be a sensitive means of determining monocytic differentiation of AMLs or myeloid sarcoma.

Antigen detection, in tissues and cells, is a multi-step immunohistochemical process. The initial step binds the primary antibody to its specific epitope. After labeling the antigen with a primary antibody, an affinity-purified, secondary antibody is added to bind to the primary antibody. An enzyme label is then added to bind to the secondary antibody; this detection of the bound antibody is evidenced by a colorimetric reaction.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

10D6

Isotype

IgG1

Antigen

CD163

Localization

Membrane

Positive Control

Tonsil or Placenta

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Lee CH, et al. Clin Cancer Res. 2008 Mar 1; 14(5):1423-30.
2. Lau SK, Chu PG, Weiss LM. Am J Clin Pathol. 2004 Nov; 122(5):794-801.
3. Nguyen TT, et al. Am J Surg Pathol. 2005 May; 29(5):617-24.

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