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CD15 MMA antibody is reported to be present on greater than 90% of granulocytes including neutrophils and eosinophils and to a lesser degree, on monocytes. CD15 has been reported to be expressed in Reed-Sternberg cells of Hodgkin’s disease (of the nodular sclerosis, mixed cellularity and lymphocyte-depleted subtypes) and certain types of epithelial cells. It is generally agreed that the Reed-Sternberg cell variants in lymphocyte-predominant Hodgkin’s disease are not reactive with CD15.
CD15 Cocktail [MMA + BY87] is comprised of two mouse monoclonal antibodies intended for laboratory use in the qualitative identification of CD15 protein on the cell surface of granulocytes and monocytes by immunohistochemistry (IHC) in formalin-fixed paraffin-embedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist.
Antigen detection in tissues and cells is a multi-step immunohistochemical process. The initial step binds the primary antibody to its specific epitope. A secondary antibody may be applied to bind the primary antibody, followed by an enzyme labeled polymer; or an enzyme labeled polymer may be applied directly to bind the primary antibody. The detection of the bound primary antibody is evidenced by an enzyme-mediated colorimetric reaction.
Surface membrane and paranuclear staining
Reed-Sternberg cells (Hodgkin’s)
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2. Pellegrini W, et al. Haematologica. 2007 May; 92(5):708-9.
3. Arici DS, Aker H, Güngör M. Indian J Med Res. 1999 Jan; 109:33-7.