CD117/c-kit

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CD117/c-kit antibody is a member of Tyrosine Kinase kDa (-3) Receptor (TKR) family and is highly homologous to receptor PDGF and CSF-1. This antibody recognizes the extracellular domain and is expressed by a variety of normal and abnormal cell types. In abnormal cells, CD117 has been shown to label testicular germ cells, endometrial carcinomas, papillary and follicular thyroid carcinomas, small cell carcinomas, melanomas and ovarian epithelial carcinomas. It has also been shown to be an effective marker for mast cell disorders, gastrointestinal stromal tumors and immunotyping of blasts in human bone marrow.

Intended Use

IVD

Species Reactivity

Human

Source

Rabbit Monoclonal

Clone

EP10

Isotype

IgG

Antigen

CD117

Localization

Cell membrane/cytoplasmic

Positive Control

Skin (Mast cells), gastrointestinal stromal tumor or seminoma

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Miettinen M, Sarlomo-Rikala M, Lasota J. Hum Pathol. 1999 Oct; 30(10):1213-20.
2. Arber DA, Tamayo R, Weiss LM. Hum Pathol. 1998 May; 29(5):498-504.
3. Escribano L, et al. Cytometry. 1997 Apr; 30(2):98-102.

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