Caspase-3

$118.00$741.00

Clear
SKU: 229 Categories: ,
Related Products

Apoptosis has gained central importance in the study of many biological processes, including neoplasia, neurodegenerative diseases and development. The proteases that mediate apoptosis are called caspases (cysteinyl-aspartic acid proteases). Cleaved caspase-3 antibody detects endogenous levels of the large fragment of activated caspase-3, a protease that mediates apoptosis. Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 subunits. Cleavage of caspase-3 requires aspartic acid at the P1 position. This antibody does not cross-react with other cleaved caspases.

Intended Use

IVD

Species Reactivity

Human, Mouse

Source

Rabbit Polyclonal

Clone

N/A

Isotype

N/A

Antigen

Caspase-3

Localization

Cytoplasmic, Nuclear

Positive Control

Tonsil or Colon Cancer

Download Data Sheet
Download RUO Data Sheet
Download SDS Sheet

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Gown A, Willingham MC. J Histochem Cytochem. 2002 Apr; 50(4):449-54.
2. Wang L, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Mar; 33(3):222-6.
3. Chrysomali E, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Nov; 96(5):566-72.

Reviews


There are no reviews yet.

Be the first to review “Caspase-3”