Calponin

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Calponin a 34 kDa polypeptide, is a cytoskeleton-associated actin-binding protein that also interacts tropomyosin and calmodulin. Calponin antibody has been found to be useful as a marker for myoepithelial and basal lamina in differentiating microinvasive from in situ ductal carcinomas of the breast. Calponin antibody may also have applications in malignant myoepithelium and pleomorphic adenoma of salivary gland as well as a useful marker for fine needle aspirates of papillary breast lesions.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

CALP

Isotype

IgG1/kappa

Antigen

Calponin Protein

Localization

Cytoplasmic

Positive Control

Normal Breast Glands

1. Mosunjac MB, et al. Diagn Cytopathol. 2000 Sep; 23(3):151-5.
2. Prasad AR, et al. Arch Pathol Lab Med. 1999 Sep; 123(9):801-6.
3. Damiani S, et al. Virchows Arch. 1999 Mar ;434(3):227-34.

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