Studies have shown that calcitonin antibody reacts with the human protein calcitonin and labels C-cells in normal thyroid. Calcitonin antibody has been reported to be particularly useful in differentiating medullary carcinoma from papillary and follicular thyroid cancer. Most medullary carcinomas are positive for calcitonin; conversely, most papillary and follicular types of thyroid cancer are usually negative for calcitonin. When used in conjunction with TTF-1 thyroid medullary carcinoma may be distinguishable from laryngeal moderately differentiated carcinoma.
1. Us-Krasovec M, et al. Pathologica. 1998 Feb; 90(1):5-13.
2. Kos M, Separović V, Sarcević B. Acta Med Croatica. 1995; 49(4-5):195-9.
3. Hirsch MS, Faquin WC, Krane JF. Mod Pathol. 2004 Jun; 17(6):631-6.