c-Myc

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The oncogene-encoded protein c-Myc is postulated to play a role in activating the transcription of growth related genes. Amplification of the c-Myc gene has been found in several types of human tumors. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in neoplastic disease. c-Myc oncogene activity may also be necessary for the translocation(s) seen in human breast tumors identified to have a poor-prognosis signature. Over-expression of the c-Myc oncogene has been implicated in the development and progression of human prostate carcinoma.

Intended Use

IVD

Species Reactivity

Human

Source

Rabbit Monoclonal

Clone

EP121 (previously known as Y69)

Isotype

IgG

Antigen

Synthetic peptide corresponding to residues in N-terminus of human c-Myc

Localization

Nucleus

Positive Control

Some prostate or breast cancer

1. Wolfer A, et al. Proc Natl Acad Sci U S A. 2010 Feb; 107(8):3698-703.
2. Gurel B, et al. Mod Pathol. 2008 Sep; 21(9):1156-67.
3. Park K, et al. Hum Pathol. 2005 Jun; 36(6):634-9.
4. Yang G, et al. Cancer. 2005 Mar; 103(6):1186-94.

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