BRCA-1

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The BRCA-1 antibody gene codes for a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. Findings suggest that BRCA-1 antibody plays a protective role in epithelial cells undergoing high levels of proliferation in association with differentiation. Additional studies have shown that the complete loss of BRCA-1 nuclear expression and the correlation with poor prognostic markers in breast cancer imply that the altered BRCA-1 phenotype may provide an added prognostic parameter for breast cancer and could be applied as a potential rapid screening technique for BRCA-1 mutations.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

MS110

Isotype

IgG1

Antigen

BRCA-1

Localization

Nuclear

Positive Control

Breast cancer

1. Ribeiro-Silva A, et al. Histopathology. 2005 Nov; 47(5):458-66.
2. Ansquer Y, et al. Anticancer Res. 2005 Nov-Dec; 25(6C):4535-41.
3. Kurebayashi J, et al. Anticancer Res. 2006 Jan-Feb; 26(1B):695-701.
4. Jarvis EM, Kirk JA, Clarke CL. Cancer Genet Cytogenet. 1998 Mar; 101(2):109-15.

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